ASSESSMENT OF THE INTENSITY OF SYSTEMIC INFLAMMATION IN PATIENTS WITH OPIOID DEPENDENCE
DOI:
https://doi.org/10.32782/3083-7324/2025.1.5Keywords:
opioid dependence, systemic inflammation, interleukin-6, cytokines, chronic hepatitis C.Abstract
The aim of the study was to assess the intensity of systemic inflammation by evaluating serum interleukin-6 (IL-6) levels in patients with opioid dependence (OD) and in those with OD comorbid with chronic hepatitis C (CHC). A total of 135 patients with opioid depend- ence (104 men and 31 women) aged 18–49 years were examined, including 95 patients with comorbid chronic hepatitis C (75 men and 20 women) aged 19–49 years. All patients underwent dynamic measurement of serum IL-6 levels. Discriminant analysis of this pro-in- flammatory cytokine across groups with OD and OD combined with CHC at different stages of the disease showed that the most pronounced intergroup differences were observed during remission (F = 67.6; p < 0.001) and the late withdrawal period (F = 41.4; p < 0.001). Less prominent differences were detected during acute intoxication (F = 13.7; p < 0.001) and the early withdrawal period (F = 6.9; p < 0.001).
References
1. Butelman E. R., Huang Y., Cathomas F., et al. Serum cytokines and inflammatory proteins in individuals with heroin use disorder. Transl Psychiatry. 2024. No. 14. Р. 414. DOI: 10.1038/s41398-024-03119-z.
2. Bryant B. M., Eaton E., Li L., et al. A systematic review of opioid use disorder and related biomarkers. Front Psychiatry. 2021. No. 12. 708283. DOI: 10.3389/fpsyt.2021.708283.
3. Hearps A. C., Doyle J. S., Hellard M. E., et al. Injecting drug use and HCV infection drive persistent immune activation. Open Forum Infect Dis. 2024. No. 11. ofad623. DOI: 10.1093/ofid/ofad623.
4. Grebenciucova E., VanHaerents S. Interleukin-6: at the interface of health and disease. Front Immunol. 2023. No. 14. 1255533. DOI: 10.3389/fimmu.2023.1255533.
5. Wen S., Song X., Wang J., et al. Opioids regulate macrophage cytokine production. Front Pharmacol. 2022. No. 13. 814241. DOI: 10.3389/fphar.2022.814241.
6. Che Noh I., Avoi R., Nurul A. A., et al. Cytokine profile in chronic HCV infection. PeerJ. 2022. No. 10. e13330. DOI: 10.7717/peerj.13330.
7. Mititelu A., Grama A., Colceriu M. C., et al. Role of IL-6 in acute pancreatitis. Int J Mol Sci. 2024. Vol. 25. 8283. DOI: 10.3390/ijms25158283.
8. Słowińska-Solnica K., Pawlica-Gosiewska D., Gawlik K., et al. IL-6 in Crohn’s disease. Arch Med Sci. 2021. No. 17. Р. 252–257. DOI: 10.5114/aoms/130842.
9. Schmidt-Arras D., Rose-John S. IL-6 pathway in the liver. J Hepatol. 2016. No. 64. Р. 1403–1415. DOI: 10.1016/j.jhep.2016.02.004.
10. Al-Qahtani A. A., Al-Anazi M. R., Al-Qahtani A. A., & Aljarbou A. N. IL-6 in infectious diseases. Trop Med Infect Dis. 2024. No. 9. Р. 13. DOI: 10.3390/tropicalmed9010013.
11. Rafaqat S., Patoulias D., Behnoush A.H., et al. Interleukins in pancreatitis. Arch Med Sci. 2024. No. 20. Р. 138–156. DOI: 10.5114/aoms/178183.
12. Wang H., Zhao M., Xiang Y., et al. Effects of opioids on IL-6 in chronic pain. Pain Ther. 2022. Vol. 11. P. 455–468. DOI: 10.1007/s40122-022-00386-w.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Микола Олексійович Овчаренко, Віталій Євгенович Казаков, Леонід Леонідович Пінський (Автор)
This work is licensed under a Creative Commons Attribution 4.0 International License.
